Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches
PMID: 35025127
Experiments
- Calculate the accuracy in search for BALB/cJ and SWR/J mice.1
- Estimate the relative search diameter (δRS) for both BALB/cJ and SWR/J mice.2
- Determine the relative search intensity (rIcs) for BALB/cJ and SWR/J mice.3
- We analyzed the WM swim trajectories of BALB/cJ and SWR/J mouse strains using divergence heat maps to show distinct convergence hotspots for groups of mice on different probe days.
- Quantify the accuracy of search center for both Ptpn11+/+ and Ptpn11D61G/+ mice.1
- Assess the uncertainty in search center in terms of relative search diameter (δRS).2
- Determine the relative intensity of search (rIcs) at the search center for both Ptpn11+/+ and Ptpn11D61G/+ mice.3
- We analyzed the water maze performance of Ptpn11D61G/+ mice and their wild type littermates, showing convergence peaks adjacent to the platform location using divergence heat maps.
- Quantify the accuracy of search center for saline-treated and SL327-treated conditions.1
- Measure the uncertainty in spatial memory (δRS) for both saline-treated and SL327-treated conditions.2
- Compare the relative search intensity (rIcs) between saline-treated and SL327-treated conditions.3
- We analyzed the swim trajectories of Ptpn11N308D/+ and their wild type littermates on PD5 and evaluated the effect of SL327 on accuracy and uncertainty of search.
- Identify the convergence hotspots for both old and new platform locations.1
- Quantify the accuracy, uncertainty, and relative search intensity (rIcs) for the platform locations on PD3 and PD5.2
- Calculate the goal reversal efficiency measure (GRE).3
- We analyzed the performance of C57Bl/6J and DBA/2J strains of mice in a goal reversal task using divergence heat maps.
Description of spatial memory in BALB/cJ and SWR/J strain of mice using the three parameters: Accuracy (α), uncertainty (δRS), and intensity of search (Ics)
Instructions
Methodologies
Description of MWM spatial memory in Ptpn11D61G/+ and wild type littermates (Ptpn11+/+) using the three parameters accuracy (α), uncertainty (δRS), and intensity of search (Ics)
Instructions
Methodologies
Accuracy and uncertainty are able to detect the rescuing of spatial memory deficits seen in Ptpn11N308D/+ mice by the administration of SL327
Items
| Material | Material Usage | Supplier |
| MEK inhibitor SL327 | Injected intraperitonially everyday 30 min before MWM training | N/A |
Instructions
Methodologies
Convergence hotspots detects the memory for old as well as new platform location in goal reversal task
Instructions
Methodologies
